INFO:

Ephenidine (also known as NEDPA and EPE) is a lesser-known novel dissociative substance of the diarylethylamine class. Ephenidine is an NMDA receptor antagonist that is structurally related to diarylethylamines like diphenidine and methoxphenidine. Notable effects include sedation, hallucinations, anesthesia, and out-of-body states, referred to as "dissociative anesthesia".

Ephenidine and related diarylethylamines have been studied in humans as treatments for neurotoxic injuries. Recreational use was not documented until the 2013 U.K. arylcyclohexylamine ban, when it was released on the online research chemical market. It was marketed alongside diphenidine and methoxphenidine as a substitute for methoxetamine(MXE) despite users claiming markedly different effects.

Very little data exists about the pharmacological properties, metabolism, and toxicity of ephenidine, and it has an extremely limited history of human usage. The abuse of diarylethylamines has been linked to a number of fatal and non-fatal overdoses. Many reports suggest that they may pose different risks than traditional dissociatives. It is highly advised to use harm reduction practices if using this substance.

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